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      我的購物車>> 中國區首家總代 專業十六載 打造細胞生物學精品
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      您當前所在位置:首 頁 > 產品展示 > 人類 > 視覺細胞系統 人視網膜色素上皮細胞 HRPEpiC

      人視網膜色素上皮細胞 HRPEpiC

      英文名:Human Retinal Pigment Epithelial Cells

      貨號:6540

      價格:$718

      產品說明書下載:

      產品預訂,提交訂單信息之后,我們會第一時間與您取得聯系!
      視網膜是位于眼睛后部的多層結構。它包括感光細胞和視網膜色素上皮細胞(RPEpiC)。RPEpiC位于神經視網膜和脈絡膜之間,形成視網膜外屏障,控制著視網膜下腔的化學構成。人們發現RPEpiC內有許多特定偏振分布的細胞內蛋白質。與其他上皮細胞通常頂生面沒有基質相比,RPEpiC的頂生面胞膜是與細胞外基質相接觸的。RPEpiC在調節相鄰的感光膜周轉、維生素A的代謝、保護細胞內黑色素所致的視網膜光損害中起關鍵作用。RPEpiC與很多視網膜疾病的發病相關,如增殖性視網膜病變和年齡相關性黃斑變性。
      Sciencell研究實驗室的HRPEpiC是從人視網膜分離得到的,原代凍存,冰凍運輸。每管細胞密度超過5×10^5/ml。細胞特性經cytokeratine?-18,?-19和纖維粘連蛋白免疫熒光鑒定。本細胞經檢測不含HIV-1、HBV、HCV、支原體、細菌、酵母菌和真菌。如采用ScienCell?實驗室特制的培養基,可保證此細胞10倍增增殖。


      推薦培養基:
      上皮細胞培養基 (EpiCM, Cat. #4101)
      貨號6540
      產地美國
      縮寫HRPEpiC
      規格5 x 10^5 /1ml
      用途科研
      儲存液氮
      運輸干冰
      1.) Favret S, Binet F, Lapalme E, Leboeuf D, Carbadillo J, Rubic T, Picard E, Mawambo G, Tetreault N, Jean- Joyal S, Chemtob S, Sennlaub F, SanGiovanni JP, Guimond M,Sapieha P. (2013) "Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions."?Aging (Albany NY). 5: 427.

      2.) Miyamoto N, Izumi H, Miyamoto R, Bin H, Kondo H, Tawara A, Sasaguri Y, Kohno K. (2011) "Transcriptional Regulation of Activating Transcription Factor 4 under Oxidative Stress in Retinal Pigment Epithelial ARPE-19/HPV-16 Cells."?Invest Ophthalmol Vis Sci. 52: 1226-34.

      3.) Narayan S, Prasanna G, Tchedre K, Krishnamoorthy R, Yorio T. (2010) "Thrombin-induced endothelin-1 synthesis and secretion in retinal pigment epithelial cells is rho kinase dependent."?J Ocul Pharmacol Ther. 26: 389-97.?

      4.) Bertram KM, Baglole CJ, Phipps RP, Libby RT. (2009) "Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration."?Am J Physiol Cell Physiol. 297: C1200-10.

      5.) Mannermaa E, Vellonen KS, Ryh?nen T, Kokkonen K, Ranta VP, Kaarniranta K, Urtti A. (2009) "Efflux protein expression in human retinal pigment epithelium cell lines."Pharm Res. 26: 1785-91.

      6.) Cheong HI, Johnson J, Cormier M, Hosseini K. (2008) "In vitro cytotoxicity of eight beta-blockers in human corneal epithelial and retinal pigment epithelial cell lines: comparison with epidermal keratinocytes and dermal fibroblasts."?Toxicol In Vitro. 22: 1070-6.

      7.) Swaney JS, Moreno KM, Gentile AM, Sabbadini RA, Stoller GL. (2008) "Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye."?Exp Eye Res.?87: 367-75.

      8.) Hunt DW, Boivin WA, Fairley LA, Jovanovic MM, King DE, Salmon RA, Utting OB. (2006) "Ultraviolet B light stimulates interleukin-20 expression by human epithelial keratinocytes."?Photochem Photobiol. 82: 1292-300.
      ?

      Question:

      Regarding Human Retinal Pigment Epithelial Cells Catalog #6540 Are the cells from a single human donor or multiple in a pool? If single donor, can one order vials from a few donors to compare? Can you provide a list of available donors and their characteristics? I have read the following paper where this product is used and they make the comment that they conducted their work with hRPEpC in multiple donors. Toxicol Sci. 2015 Mar;144(1):163-72. Retinal Toxicity, in vivo and in vitro, Associated with Inhibition of Nicotinamide Phosphoribosyltransferase.


      ? Answers:

      • Hi Elizabeth,

        it is Single donor.if you are interested in multiple vials from different lots to get different donors. Please contact us at techsupport@sciencellonline.com to obtain donor information.
        Thanks for your interest in our products.

        SCIENCELL TEAM?

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      99久久香蕉国产线看观看

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