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ScienCell's GeneQuery? Human PD-1/PD-L1 Checkpoint Pathway qPCR Array Kit (GQH-PDI) is designed to facilitate gene expression profiling of 88 key genes involved in human PD-1/PD-L1 checkpoint pathway, and to help identifying potential prognostic biomarkers for cancer immunotherapy.? PD-1/PD-L1 checkpoint pathway plays an important role in the maintenance of T cell stability, as well as mediating inhibitory signals for proliferation and function of T effector cells. PD-1/PD-L1 immune checkpoint blockade has resulted in enhancement of T cell immunity against tumors and viral pathogens. Brief examples of how genes may be grouped according to their functions are shown below:?????

• ??Co-stimulatory/inhibitory receptors:?PDCD1 (PD-1), CD28, CD27, CD276, ICOS, TNFRSF18, TNFRSF4, TNFRSF9
• ??Co-stimulatory/inhibitory pathway:?CD274 (PD-L1), PDCD1LG2 (PD-L2), CD4, LCK, CD2, CD247, CSK, PTPN11, PTPN2, PTPN6, NCOR2
• ??PD-L1 induction:?IFNG, IL15, IL17A, IL2, IL21, IL7, MAPK1, NRP1, STAT3
• ??T cell receptor signaling:?AKT1, CD3, CTLA4, CD8, GSK3B, JUN, NFKB1, PDPK1
• ??T cell function regulation:?BATF, FOXO1, KRAS, MAPK8, MTOR, NFATC1, PI3Ks, SKP2, TLR9
• ??B cell function regulation:?CD80, CD86, POU2F2
• ??Proinflammatory molecules:?CSF2, IL4, IL10, IRF6, TNF, VEGFA
• ??Additional immune checkpoint genes:HAVCR2, HNF1A, LAG3, TIGIT
  

  Note:?all gene names follow their official symbols by the Human Genome Organization Gene Nomenclature Committee (HGNC).