BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta of signaling
proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing
bone and cartilage formation in association with osteoconductive
carriers such as collagen and synthetic hydroxyapatite. In addition to
its osteogenic activity, BMP-2 is also involved in organogenesis,
particularly in cardiac morphogenesis, as well as limb bud formation.
BMP-2 expression can be found in a variety of tissues including lung,
spleen, brain, liver, prostate ovary and small intestine.The functional
form of BMP-2 is a 26 kDa protein composed of two identical 114 amino
acid polypeptide chains linked by a single disulfide bond. Each BMP-2
monomer is expressed as the C-terminal part of a precursor polypeptide,
which also contains a 23 amino acid signal sequence for secretion, and a
259 amino acid propeptide. After dimerization of this precursor, the
covalent bonds between the propeptide (which is also a disulfide-linked
homodimer) and the mature BMP-2 ligand are cleaved by a furin-type
protease.
| 貨號 | 108-02 |
| 產地 | 美國 |
| 縮寫 | rhBMP-2 |
| 規格 | 2 μg |
| 用途 | 科研 |
| 儲存 | -20度 |
| 運輸 | 干冰 |
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