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      我的購物車>> 中國區首家總代 專業十六載 打造細胞生物學精品
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      人肝細胞 HH

      英文名:Human Hepatocytes

      貨號:5200

      價格:$726

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      產品預訂,提交訂單信息之后,我們會第一時間與您取得聯系!
      肝臟是許多重要功能的關鍵器官,包括能量代謝、外源性化學物質生物轉化、生理和病理條件下血漿蛋白合成、以及解毒作用[1]。人肝細胞是多功能細胞,包括蛋白質合成、膽固醇合成、儲存蛋白質、產生并分泌膽汁以及解毒作用[1-3]。HH是體外培養用來研究肝功能、新陳代謝和肝病非常好的模型。了解肝臟的分子機制可能有助于闡明治療肝臟疾病的新療法。
      Sciencell研究實驗室的臍靜脈內皮細胞是從人肝臟分離得到的,原代凍存,冰凍運輸。每管細胞密度超過5×10^6/ml。細胞特性經白蛋白、cytokeratin-18 and vimentin免疫熒光鑒定。本細胞經檢測不含HIV-1、HBV、HCV、支原體、細菌、酵母菌和真菌。HH不能擴大培養或者產期培養,因為它不能增殖。

      推薦培養基:肝細胞培養基 (HM, Cat. #5201)
      貨號5200
      產地美國
      縮寫HH
      規格1 x 10^6 /1ml
      用途科研
      儲存液氮
      運輸干冰
      1.) Chiang TS, Yang KC, Chiou LL, Huang GT, Lee HS.(2014) "Enhancement of CYP3A4 Activity in Hep G2 Cells by Lentiviral Transfection of Hepatocyte Nuclear Factor-1 Alpha."?PloS one. 9: e94885.

      2.) Liu Y, Liu A, Xu Z, Yu W, Wang H, Li C, Lin J. (2011) "XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells."?Apoptosis. 16: 502-10.

      3.) Braconi C, Valeri N, Gasparini P, Huang N, Taccioli C, Nuovo G, Suzuki T, Croce CM, Patel T. (2010) "Hepatitis C virus proteins modulate microRNA expression and chemosensitivity in malignant hepatocytes."?Clin Cancer Res. 16: 957-66.?

      4.) Hikita H, Takehara T, Shimizu S, Kodama T, Shigekawa M, Iwase K, Hosui A, Miyagi T, Tatsumi T, Ishida H, Li W, Kanto T, Hiramatsu N, Hayashi N. (2010) "The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib."?Hepatology. 52: 1310-21.

      5.) Liu Y, Li PK, Li C, Lin J. (2010) "Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells."?J Biol Chem. 285: 27429-39.

      6.) Shen Q, Cicinnati VR, Zhang X, Iacob S, Weber F, Sotiropoulos GC, Radtke A, Lu M, Paul A, Gerken G, Beckebaum S. (2010) "Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion."?Mol Cancer. 9: 227.

      7.) Shimizu S, Takehara T, Hikita H, Kodama T, Miyagi T, Hosui A, Tatsumi T, Ishida H, Noda T, Nagano H, Doki Y, Mori M, Hayashi N. (2010) "The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma."?J Hepatol. 52: 698-704.?

      8.) Yeon JH, Na D, Park JK. (2010) "Hepatotoxicity assay using human hepatocytes trapped in microholes of a microfluidic device."?Electrophoresis. 31: 3167-74.

      9.) Braconi C, Meng F, Swenson E, Khrapenko L, Huang N, Patel T. (2009) "Candidate therapeutic agents for hepatocellular cancer can be identified from phenotype-associated gene expression signatures."?Cancer. 115: 3738-48.?

      10.) Huang Y, Song N, Ding Y, Yuan S, Li X, Cai H, Shi H, Luo Y. (2009) "Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis."?Cancer Res. 69: 7529-37.?

      11.) Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. (2007) "MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer."?Gastroenterology. 133: 647-58.

      12.) Nahmias Y, Casali M, Barbe L, Berthiaume F, Yarmush ML. (2006) "Liver endothelial cells promote LDL-R expression and the uptake of HCV-like particles in primary rat and human hepatocytes."?Hepatology. 43: 257-65.
      ?

      Question:

      Dear Customer Service, I am Zhonghui Zhang who is working in Dr. Wen-Shu Wu’s lab at the University of Illinois at Chicago (UIC). We previously ordered your HH cells and HH medium 09/29/2008 in Maine Medical Center Research Institute (Our lab moved from MMCRI to UIC in 2013). We would like to order a new HH cells from your company, but we don’t want to order this cell from the same donor. Would you please tell me whether the cells were from different donors? By the way, would you please give us some information about previous HH cells (such as age, gender, race and etc.)? Thank you so much! Zhonghui Zhang, Ph.D Section of Hematology/Oncology, Department of Medicine University of Illinois at Chicago 909 S Wolcott Ave, Room 5140 Chicago, IL 60612 Phone: 312-996-2324 (office) or 207-420-5603 (cell)

      Answers:

      • Posted by?Manoj Sharma?on Thursday, January 7, 2016

        hello,

        We need lot number to check donor information. And yes we have other lots from different donors. thanks for your interest

        SCIENCELL TEAM

        ?

        Question:

        Can you provide more detail on the source of these cells and general characteristics other than "HH from ScienCell Research Laboratories are isolated from human liver"? Derived from healthy liver tissue, any particular liver site for selection of cellular material, how derived, normal karyotype?

        Answers:

        ?

        Posted by?Karishma Shah?on Thursday, August 27, 2015

        Hi Jeff,

        Thanks for asking! Human Hepatocytes are isolated from healthy liver tissue. We have donor information for each lot, if you would like specific information please email sales@sciencellonline.com or call us at 760-602-8549. Due to tissue limitation, there is no particular site in the liver we get cells from. We use the entire liver tissues we obtain. Please let us know if you have any more questions. Thank you!

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      99久久香蕉国产线看观看

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