99久久香蕉国产线看观看

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        我的購物車>> 中國區首家總代 專業十六載 打造細胞生物學精品
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        您當前所在位置:首 頁 > 產品展示 > 人類 > 肺細胞系統 人氣管平滑肌細胞 HTSMC

        人氣管平滑肌細胞 HTSMC

        英文名:Human Tracheal Smooth Muscle Cells

        貨號:3410

        價格:$726

        產品說明書下載:

        產品預訂,提交訂單信息之后,我們會第一時間與您取得聯系!
        ? ? 氣道平滑肌是維持氣道張力的根本。它存在于氣管、支氣管樹直至終末支氣管。其特異的超微結構特點和調節機制是實現氣管正常生理功能的基礎。有證據表明氣管平滑肌在肺的發育過程以及諸如哮喘病、慢性支氣管炎和肺氣腫等疾病狀態下經歷著顯著的表型變化。另外,氣道平滑肌通過分泌細胞因子和趨化因子等促炎介質,發揮免疫調節功能。培養的氣管平滑肌細胞能表達三種P21活化的激酶(PAK)的同型異構體和PAK1,并通過P38 mapk信號途徑參與氣管平滑肌細胞的遷移。氣道平滑肌細胞增殖已成為人們關注的焦點,因為在哮喘病人中,此細胞是氣道壁重塑反應中數量上的重要組分,并被認為是新型抗哮喘病藥物的作用目標。
        ? ? 人氣管平滑肌細胞提取于人氣管組織,二代凍存。每管含有細胞數>5×105 cells/ml,此細胞通過對alpha-SMA和Desmin免疫熒光染色驗證,經測試不含有HIV-1、HBV、HCV、支原體、細菌、酵母和真菌。細胞可以達到15倍增。? ?

        推薦培養基:平滑肌細胞培養基?(SMCM, Cat. #1101)

        貨號3410
        產地美國
        縮寫HTSMC
        規格5 x 10^5 /1ml
        用途科研
        儲存液氮
        運輸干冰
        1.) Timm DM, Chen J, Sing D, Gage JA, Haisler WL, Neeley SK, Raphael RM, Dehghani M, Rosenblatt KP, Killian TC, Tseng H, Souza GR. (2013) 'A high-throughput three-dimensional cell migration assay for toxicity screening with mobile device-based macroscopic image analysis.'

        2.) Timm DM, Chen J, Sing D, Gage JA, Haisler WL, Neeley SK, Raphael RM, Dehghani M, Rosenblatt KP, Killian TC, Tseng H, Souza GR. (2013) "A high-throughput three-dimensional cell migration assay for toxicity screening with mobile device-based macroscopic image analysis."?Sci rep. 3.

        3.) Cheng SE, Lee IT, Lin CC, Kou YR, Yang CM. (2010) "Cigarette smoke particle-phase extract induces HO-1 expression in human tracheal smooth muscle cells: role of the c-Src/NADPH oxidase/MAPK/Nrf2 signaling pathway."?Free Radic Biol Med. 48: 1410-22.

        4.) Lee CW, Lee IT, Lin CC, Lee HC, Lin WN, Yang CM. (2010) "Activation and induction of cytosolic phospholipase A2 by IL-1beta in human tracheal smooth muscle cells: role of MAPKs/p300 and NF-kappaB."?J Cell Biochem. 109: 1045-56.

        5.) Cheng SE, Luo SF, Jou MJ, Lin CC, Kou YR, Lee IT, Hsieh HL, Yang CM. (2009) "Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1, and NF-kappaB in human tracheal smooth muscle cells."?Free Radic Biol Med. 46: 948-60.

        6.) Lin WN, Luo SF, Lin CC, Hsiao LD, Yang CM. (2009) "Differential involvement of PKC-dependent MAPKs activation in lipopolysaccharide-induced AP-1 expression in human tracheal smooth muscle cells."?Cell Signal. 21: 1385-95.?

        7.) Luo SF, Chang CC, Lee IT, Lee CW, Lin WN, Lin CC, Yang CM. (2009) "Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells."?Toxicol Appl Pharmacol. 237: 8-21.?

        8.) Yang CM, Lee IT, Lin CC, Yang YL, Luo SF, Kou YR, Hsiao LD. (2009) "Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB pathway and p300 in tracheal smooth muscle cells."?Am J Physiol Lung Cell Mol Physiol. 297: L892-902.

        9.) Lee CW, Lin CC, Luo SF, Lee HC, Lee IT, Aird WC, Hwang TL, Yang CM. (2008) "Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells."?Mol Pharmacol. 73: 1454-64.

        10.) Liang KC, Lee CW, Lin WN, Lin CC, Wu CB, Luo SF, Yang CM. (2007) "Interleukin-1beta induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells."?J Cell Physiol. 211: 759-70.

        11.) Song Y, Qi H, Wu C. (2007) "Effect of 1,25-(OH)2D3 (a vitamin D analogue) on passively sensitized human airway smooth muscle cells."?Respirology. 12: 486-94.
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        99久久香蕉国产线看观看
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